Main Street Inn

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221 E Main St
Vermillion, SD 57069
5 Bedroom Bed and Breakfast that is walking distance from downtown, the parks, the University, and many Churches. Historic Fraternity House built in 1919 by the Beta Theta Pi's and cared for by the Sigma Nu's since the 1970's. Thousands of young men lived in this building for over a century. The rooms all have private bathrooms with heated floors and personal AC/heating. 3 of the rooms have a single King Bed and 2 have two queen beds. This is a great location to stay if you are looking for something with a little more style and service.

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5.04 reviews
Photo of Joanne L.
Joanne L.
8/23/2025

Dropping your kids off at college for the first time is an overwhelming and emotional experience, but having somewhere so welcoming to return to is truly priceless. The Main Street Inn has thought...

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Dan G.
7/17/2025

Cannot say enough good things about this B & B in Vermillion! From the meticulous attention to architectural restoration of a former college fraternity house into a 5 bedroom mission style inn,...

Robert L R.
11/8/2023

The rooms are spacious, well furnished with custom made oak pieces by Amish craftsmen. The bed was very comfortable. And rooms, baths and common areas are kept very clean. This is also a...

Aaron L.
6/30/2022

What a great remodel of an older fraternity building! Located within steps of downtown Vermillion, this place is awesome! Stayed here with my girlfriend and another couple to visit...

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