Lewis Drug

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6109 S Louise Ave
Sioux Falls, SD 57108

Lewis Drug is a community-focused retail pharmacy and general store located in Sioux Falls, South Dakota, offering a wide array of products including grocery items, outdoor living essentials, and wellness services. The store prides itself on providing simple and rewarding shopping experiences, with special promotions like Senior Day discounts and noteworthy local partnerships through their Lewis Cares initiative.

In addition to everyday essentials, Lewis Drug features unique items such as seasonal garden products and collectable merchandise, including a commemorative bobblehead in honor of Captain 11’s anniversary. With an emphasis on local engagement and customer satisfaction, Lewis Drug is dedicated to enhancing the lives of its patrons and supporting the community.

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Reviews

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2.55 reviews
Photo of Courtney D.
Courtney D.
10/10/2018

I love Lewis. It's great to be able to pop in and out and find what I need. I also use them for my pharmacy as well. They have a great location close to my home so it's really convenient when I...

Theresa H.
9/18/2025

Sanford is buying out all the Lewis drug locations and they're saying nothing will change. But according to sources they are getting rid of the customer service area where stamps and para transit...

Timothy D.
5/28/2025

Not sure if all of you are aware. Lewis Drug has made the decision to not support the only insurance that American Service Members and their dependents have. Tricare is the health insurance of...

Hanna R.
10/22/2018

I believe this is the newest Lewis in town. It is well organized and a great place to stop by if you need literally anything. The people here are great and always smiling! I really feel at home at...

Hannah L.
6/26/2014

I never complained about bad customer service. It's just today at Lewis on Louise Ave that somehow is making my blood boil. I went to mail some postcards to Canada. The lady saw that I used the...

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