Sassafras Southern Bistro

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(515)

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103 N Main St Ste 107
Greenville, SC 29601
Located in the heart of downtown Greenville, South Carolina, Sassafras Southern Bistro serves an eclectic menu of American cuisine with a truly Southern influence. Menu items include steak, fresh seafood, salads, and amazing desserts. Sassafras Southern Bistro has a full bar featuring local beers on tap and an extensive wine selection both by the glass and by the bottle.Start out your meal at Sassafras Southern Bistro with one of their amazing appetizers like the spicy pork tenderloin or the famous blue crab and pepper-jack nachos. Choose from entrees like the raved about shrimp and grits or the filet with house made pimento. Some vegetarian and gluten free options are available upon request.

Reviews

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4.5515 reviews
J J.
10/15/2025

A wonderful dinner! Nice presentation, timely service and great prices! We were pleased to luck into this spot. It appears to be very popula!

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Brian V.
5/21/2025

Sat at the end of the bar in front of a tv. I started out with a Manhattan to drink. Then I decided to try a bowl of their she crab soup. Although it hasn't arrived yet! Upon request, it's on the...

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Spencer F.
10/24/2025

Great food friendly service and reasonable prices! A nice lively atmosphere. I had a dark and stormy to start my wife had a Manhattan. The drinks were well made and they had a decent pour of...

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Julie C.
10/25/2025

Delicious!! Decided to do a table of appetizers. Best decision. It was so much food and we all of course shared. Service was amazing. We had the best waitress who was very attentive and one...

Doug M.
10/17/2025

The food was excellent, and the value based on portion size was incredible. I recommend the pimento cheese fondue as a starter. Our server Sarah was awesome, and offered advice on her favorites...

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United StatesSouth CarolinaGreenvilleSassafras Southern Bistro

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