Santee Seafood Bistro

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(116)

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648 Bass Dr
Santee, SC 29142

Located in the charming town of Santee, SC, Santee Seafood Bistro beckons seafood enthusiasts with its tantalizing menu and cozy ambiance. The restaurant stands out for its dedication to serving fresh, locally sourced seafood, making it a go-to spot for those craving a taste of the sea.

Whether you're a fan of classic seafood dishes or eager to try something new, Santee Seafood Bistro has something for every palate. From succulent shrimp scampi to crispy fish tacos, each dish is crafted with care and expertise, promising a delightful dining experience for all who walk through its doors.

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Reviews

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4.0116 reviews
Photo of Robert P.
Robert P.
10/5/2025

Fresh seafood, engaged service, and a funky, informal vibe. We found Santee Seafood Bistro by accident after a wrong turn on I-95 and decided to try it on our next trip there. It's really just off...

Photo of Pamela J.
Pamela J.
9/24/2025

The cutest little place very close to I-95. Definitely worth stopping for lunch or dinner while driving through. Staff is beyond friendly and accommodating and you can sit inside or out. The...

Laurie B.
10/18/2025

Food was greasy and scallops were under cooked. The seafood platter was small for the price and undercooked. The hush puppies were awesome.

Photo of Joshua R.
Joshua R.
12/21/2024

If you want good seafood and friendly service you need to come here! We came in from a long day on the road and felt like we arrived home. The staff were very nice and we were able to get seated...

Photo of Cassie M.
Cassie M.
5/30/2024

I stopped here on my road trip back from Charleston to Richmond. It was fairly empty, but it was on the later side for lunch around 1:30. Our waitress was friendly, the service was quick, & prices...

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