Sister's Cafe

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308 S Main St
Pendleton, OR 97801

Sister's Cafe, situated in the heart of Downtown Pendleton, has been a beloved culinary destination since 2012. The cafe boasts a diverse menu featuring an array of dishes, from sandwiches and soups to sweet and savory crepes, flatbread pizzas, and a selection of beverages including espresso, beer, and wine.

Upon entering Sister's Cafe, guests are greeted by a warm and inviting ambiance and a team of friendly staff. The attention to detail and quality shines through in every dish, from the mouthwatering smoked brisket sandwich to the vegan-friendly portobello wrap, all crafted with fresh ingredients and impeccable presentation.

Known for its generous portions and delightful flavors, Sister's Cafe has become a go-to spot for locals and travelers alike. Whether seeking a relaxing spot with free Wi-Fi to enjoy a meal or a culinary experience that caters to various tastes, Sister's Cafe offers a memorable dining experience in Pendleton.

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Reviews

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4.0283 reviews
Photo of Frank C.
Frank C.
7/12/2025

Stopped here for a quick lunch on my way east and I'm so glad I did! The Summer Salad was terrific! Very tasty and full of fresh berries. The space is large but cozy and full of character....

Photo of Lisa F.
Lisa F.
10/21/2025

Fabulous food and atmosphere ! A must have the mixed berry crepe ! Just be prepared to share because it is definitely huge !

Photo of Jessy M.
Jessy M.
4/26/2025

We came here for brunch and I had the Cobb and my husband the brisket Benedict. Service was great. Restaurant is super cute, they have a stage so prob live music at night and on the weekends. Good...

Photo of P. J. K.
P. J. K.
3/19/2025

One of my favorite stops in Pendleton for lunch. The food is delicious, the vibe right on, and plenty of seating!

Alan E.
10/11/2025

Went for dinner. Off season and not busy. Appeared to be a number of local residents who knew each other. Good service and plenty of options. Quality and quantity was good. VERY clean even...

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