Oklahoma Frontier Drug Store Museum

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214 W Oklahoma Ave
Guthrie, OK 73044

The Oklahoma Frontier Drugstore Museum in Guthrie, OK is a captivating destination that showcases an extensive collection of artifacts and memorabilia related to frontier pharmacies, early drugstores, and medical arts.

Located in Guthrie, the First Capital of the Oklahoma Territory and the State of Oklahoma, this museum invites visitors to explore its site, support its collections, and admire the beauty of the Apothecary Garden.

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5.012 reviews
Photo of Trisha L.
Trisha L.
9/29/2025

I had such an incredible time visiting the Oklahoma Frontier Drug Store Museum in Guthrie when I was visiting my sister in Oklahoma. I was a pharmacy technician for 20 years and I'm now a...

Photo of PJ M.
PJ M.
11/7/2025

This museum brings the 1889 Land Run era to life through an impeccably preserved 19th-century pharmacy. The 1923 soda fountain, brass scales, vintage tonics, and apothecary garden out back...

Steven M.
7/9/2023

Wow! Would you like to see what the old drug stores use to look like? It is full of brands that are long gone. Equipment that was use way back when. There are literally thousands of things that...

Photo of Ralphie S.
Ralphie S.
4/8/2018

Working in the pharmaceutical industry, I knew that I had to stop and check out this small drug store museum. It is housed in an old drug store and is fairly small, but it is jam packed with...

Photo of Michele B.
Michele B.
7/1/2017

This museum is a treasure trove of antique pharmaceuticals from our great grandparents and grandparents time. Walk back in time and visit an old fashioned soda fountain. See all kinds of potions...

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