Nicolino Valerio Valerio Dorrello, MD

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3959 Broadway
New York, NY 10032
Dr. Nicolino Valerio Dorrello is an Assistant Professor in the Division of Pediatric Critical Care Medicine, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons since 2015. He obtained his MD from University of Naples (Italy) in 2000 and his PhD in Molecular Oncology at New York University in 2004, focusing on the role of ubiquitin mediated proteolysis in cell cycle regulation. He then completed a residency in Pediatrics at the University of Padua (Italy) in 2010 and a subsequent pediatric residency at Columbia University before staying for his Fellowship in Pediatric Critical Care Medicine and then as faculty. Dr. Dorrello is double board certified in Pediatrics and Pediatric Critical Care in Unites States and in Pediatrics in Europe. In his clinical duties in the pediatric critical care unit, one of the most devastating and common injuries he comes across, unfortunately, is severe, progressive lung injury. What represents a daily clinical challenge – making these patients better – has become his research passion. He has recently succeeded in developing an airway-specific method to efficiently remove only the lung epithelium (de-epithelialization) while preserving lung vasculature and architecture in anex vivo rodent model. This new functional, vascularized lung graft then enabled the attachment and engraftment of lung epithelial progenitors. Dr. Dorrello’s laboratory is focused on elucidating the optimal strategies to selectively remove defective lung epithelial cells and supportthe proliferation and differentiation of lung progenitors towards healthy epithelium and ultimately lung repair. Dr. Dorrello has published in international peer -reviewed journals of highest reputation, such as Science, Nature, Molecular Cell, PNAS, and Science Advances.
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I am a specialist in pediatric critical care medicine, which means that I take care of children in the intensive care unit. Even when very sick, children are focused on the most important things to them – recovering fully so they can go back to playing and being healthy. Their remarkable resilience and sense of wonder, even during their most vulnerable and critical times, is what gets me out of bed each morning. It is a privilege to take care of children in this setting, and my pride to be able to work with them every day. My patients are children of all ages who need advanced levels of care and monitoring in the intensive care unit, and sometimes invasive therapies. This can mean anything from a child with lung disease bad enough to need a ventilator, severe infections that cause dangerously low blood pressure, or organs that no longer work and need to be supported until a transplant can be found. My job is to support and coordinate among children and families, nurses, nutritionists, physical therapists, and other specialist doctors, so that the entire team can maintain the body’s delicate balance and allow it to function during a critical illness. In addition to my clinical work, I am the director for the Pediatric Critical Care Medicine fellowship training program. Our mission is to train future leaders in clinical medicine, scientific research, and advocacy for the needs of critically ill children and their families. I take a special interest in our fellows’ development as scholars, and their understanding of statistics and epidemiology. To that end, my own research focuses on what happens to children after they recover from critical illness and go back home to their normal lives. Do they continue to develop normally? How long does it take? What other kinds of problems might occur? How can we best help with any lingering health issues? These are the kinds of questions that I am trying to answer as both a critical care doctor and scientist by using the medical record and other sources of data on children who have recovered from critical illness. Through active research and educating physicians of the future, I hope to push medical care forward and take even better care of the sickest children in the hospital.
United StatesNew YorkNew YorkNicolino Valerio Valerio Dorrello, MD

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