MHE Research Foundation

The MHE Research Foundation, based in Brooklyn, NY, is dedicated to advancing the understanding and treatment of hereditary multiple exostoses (MHE). Led by Dr. Dominique Stickens, a renowned researcher in the field of EXT genes, the foundation focuses on unraveling the pathogenesis of MHE and developing effective diagnostic and therapeutic approaches. Dr. Stickens' groundbreaking work in identifying the EXT2 gene and creating an EXT2 knock-out mouse model has provided valuable insights into the underlying causes of MHE, paving the way for future advancements in the field.

Dr. Yu Yamaguchi, a member of the MHE Research Foundation's Scientific and Medical Advisory Board, has also made significant contributions to MHE research. His studies on the role of EXT1 heparan sulfate in bone development and the nervous system have shed light on the diverse symptoms experienced by MHE patients, including neurological and muscular impairments. Dr. Yamaguchi's creation of a conditional EXT1 knockout mouse model has facilitated genetic studies and enabled collaboration with researchers worldwide, furthering our understanding of MHE and offering potential avenues for novel treatment approaches.

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