Meyer Kattan, MD

Dr. Constantinescu has an active clinical practice at Columbia University Medical Center, including care of children with asthma, cystic fibrosis, and technology-dependent conditions (home ventilation by invasive and non-invasive means, mechanically assisted airway clearance, etc.) He participates in the Muscular Dystrophy Clinic at Columbia, for the management of pulmonary complications of neuromuscular disorders. Through the multidisciplinary Motor Neuron Center at Columbia, Dr. Constantinescu is also involved in clinical research in the area of pulmonary function in neuromuscular disease.

I am a pediatric endocrinologist with interests that include polycysytic ovary syndrome (PCOS), bone health, disorders of puberty, thyroid disorders, pituitary disorders and growth disorders. In addition to my training in pediatrics and pediatric endocrinology, I have Master of Science degrees in Nutrition (1999) and in Patient Oriented Research (2014) and have completed a research fellowship at the Body Composition Unit of Columbia University Medical Center (2003). I comleted the TRANSFORM KL2 program sponsored by the Irving Institute of Clinical and Translational Research, a mentored career development program. My responsibilites include my clinical practice, overseeing clinical and research fellows, mentoring students, and running a clinical study. I have been certified as a clinical densitometrist by the International Society of Clinical Densitometry and interpret pediatric bone mineral density studies performed at Columbia University Irving Medical Center. My research project, “A double-blind placebo-controlled randomized clinical trial assessing the efficacy of metformin for hepatic fat in adolescents and young adults with polycystic ovary syndrome” has the primary goal of exploring the use of novel and noninvasive testing and a pilot double-blind placebo-controlled trial of metformin with the intention of identifying and potentially treating non-alcoholic fatty liver disease in adolescents and young adults with PCOS. My research is unique in that it uses minimally invasive body composition methodology, which makes it particularly attractive for use in adolescents and young adults. My overall clinical research goal is early identification and treatment of metabolic and body composition abnormalities associated with PCOS and to prevent lifelong morbidity associated with this disorder in a young population

I am a board-certified pediatric pulmonologist and sleep medicine specialist, with extensive experience in cystic fibrosis, asthma, and global health. My deep passion for correcting health disparities globally and in populations affected by asthma and cystic fibrosis regionally is strongly rooted in my upbringing. My father was a New York-trained pediatrician, and a supportive and motivating role model who shaped my life-changing commitment to community service. As a result, following medical training, pediatric specialty training, and pediatric pulmonary subspecialty training in the United States, I was committed to serve the underserved from afar. I have had the privilege of working with the pediatric pulmonary team at Columbia University Irving Medical Center (CUIMC) since 2000. My early years at CUIMC were influenced by Professor Robert (Bob) Mellins until his passing in 2012. While working in Stamford Hospital in Stamford, Connecticut during the last year of my pulmonary fellowship, I became acutely aware of the underserved needs of a sick pediatric population in southern Connecticut that, for various reasons, did not have access to care. I established a pulmonary practice in this region and became engaged in program development in three main areas: cystic fibrosis, asthma and global health. I also established a cystic fibrosis care clinic in Stamford Hospital, which led to my current position as the director of the Sue and John L. Weinberg Cystic Fibrosis Center at Columbia. In addition to my clinical practice, I have been involved in research in asthma, RSV bronchiolitis, and cystic fibrosis. In recent years, grants from the CF Foundation and CF Foundation’s therapeutic and development network have enabled me to focus my research on cystic fibrosis.