Humane Society of Southeast Missouri

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2536 Boutin Dr
Cape Girardeau, MO 63701

The Humane Society of Southeast Missouri, located in Cape Girardeau, is a no-kill pet center dedicated to nurturing the human-pet bond through shelter care and advocacy for homeless animals. Their mission includes providing spay and neuter resources and education, ensuring better lives for both pets and their communities.

The organization features an all-new Adoption Humane Education Center that exceeds state regulations, offering improved living conditions for pets and a space for humane education programs. By encouraging empathy and compassion, they aim to enhance the connections between people and animals while expanding their services for the community.

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Reviews

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3.53 reviews
Kim G.
7/13/2025

Female dog found at Huddle House on interstate 57 exit 12. It's across the street from Love's travel stop. I fed her and gave her water. She was hungry.

K. A.
5/28/2020

I went to the Humane Society the other day, in order to attempt to look at and possibly adopt a puppy I was interested in. The lady brought out the dog, which was wet and had feces on its shoulder...

Logan K.
4/2/2019

We adopted a 8 month old Shepherd/Great Dane mix from this wonderful facility. They went above and beyond to work with us as this was an out of state adoption. The staff was incredibly helpful...

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