Brody Lab

The Brody Lab at the University of Michigan is dedicated to exploring the molecular signals that contribute to the onset and progression of cardiac diseases. Their research focuses on understanding how intracellular signaling is regulated by lipid modifications in various heart cell types, utilizing advanced techniques in mouse genetics, biochemistry, and molecular biology.

Currently, the lab is investigating the role of the zDHHC family of S-acyltransferase enzymes in cardiac cell signaling, particularly how palmitoylation affects cardiomyocyte functions. Their broader aim includes developing pharmacological strategies to inhibit intracellular signaling pathways that lead to cardiac hypertrophy and failure.

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