Relay Therapeutics

Alexion Pharmaceuticals is engaged in the discovery and development of therapeutic products aimed at treating patients with an array of diseases, including hematologic and cardiovascular disorders, autoimmune diseases and cancer. Alexion's two primary product candidates, pexelizumab and eculizumab, are currently undergoing evaluation in several clinical development programs with the Federal Drug Administration. Alexion is engaged in discovering and developing a pipeline of additional antibody therapeutics targeting severe unmet medical needs, through its wholly owned subsidiary, Alexion Antibody Technologies. During the fiscal year ended July 31, 2005, eculizumab was in Phase III clinical development for treatment of paroxysmal nocturnal hemoglobinuria , a chronic hematologic disease, and pexelizumab was in clinical development for two acute cardiac indications. Alexion is also pursuing additional potential indications for eculizumab and has other product candidates in earlier stages of development. Alexion Pharmaceuticals is based in Cheshire, Conn.

Repligen Corporation develops novel therapeutics for the treatment of diseases of the central nervous and immune systems. It provides clinical development programs for the areas of schizophrenia, obsessive-compulsive disorder, bipolar disorder, multiple sclerosis and lupus. Repligen markets two niche products, Protein A and SecreFlo. Protein A is a consumable reagent used by the pharmaceutical industry to manufacture a class of drugs called monoclonal antibodies. The company offers a number of products based on recombinant Protein A, which include recombinant Protein A, Immobilized Protein A and Protein A ELISA Kits. SecreFlo is approved by the Food and Drug Administration to aid in the diagnosis of pancreatic exocrine dysfunction and gastrinoma and to aid in the identification and cannulation of the pancreatic ducts in patients undergoing endoscopic retrograde cholangiopancreatography. Repligen Corporation was established in 1981 and is headquartered in Waltham, Mass.