Cornova

Alkermes is a worldwide pharmaceutical company that develops controlled, sustained-release injectable drugs using with its trademark ProLease and Medisorb technologies. Located in Massachusetts, the company also develops inhaled formulations from its proprietary pulmonary technology. Alkermes has partnered with Johnson & Johnson to develop Riserpdal Consta, an antipsychotic drug used in the treatment of schizophrenia. Risperdal Consta is approved for sale in more than 50 countries that include the United States, United Kingdom and Germany. In addition to a host of partnered products, the ocmpany is also active in the development of several promising proprietary products, such as Vivitrex, a long-acting injectable form of naltrexone for alcohol dependence. Alkermes is headquartered in Cambridge, Mass.

Repligen Corporation develops novel therapeutics for the treatment of diseases of the central nervous and immune systems. It provides clinical development programs for the areas of schizophrenia, obsessive-compulsive disorder, bipolar disorder, multiple sclerosis and lupus. Repligen markets two niche products, Protein A and SecreFlo. Protein A is a consumable reagent used by the pharmaceutical industry to manufacture a class of drugs called monoclonal antibodies. The company offers a number of products based on recombinant Protein A, which include recombinant Protein A, Immobilized Protein A and Protein A ELISA Kits. SecreFlo is approved by the Food and Drug Administration to aid in the diagnosis of pancreatic exocrine dysfunction and gastrinoma and to aid in the identification and cannulation of the pancreatic ducts in patients undergoing endoscopic retrograde cholangiopancreatography. Repligen Corporation was established in 1981 and is headquartered in Waltham, Mass.

Medica uses its proprietary knowledge of ion-selective electrodes and analytical microchemistry to manufacture a line of blood-testing analyzers. The company is engaged in the development of new technology that it will use to base future analyzers with the same characteristics. Its growth is a result of strategic focus on the worldwide need to lower health care costs. Medica is located in Bedford, Mass.