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The ALS Therapy Development Institute (ALS TDI) is a nonprofit biotech organization based in Watertown, Massachusetts, dedicated to ending amyotrophic lateral sclerosis (ALS) through a comprehensive drug discovery approach. It is the world's largest lab focused exclusively on ALS, fueled by community support and aimed at developing multiple treatments for the disease.

With a mission to discover and invent effective treatments, ALS TDI's research is informed by the ALS Research Collaborative (ARC), a global initiative that gathers valuable data from individuals affected by ALS. The organization operates as a drug discovery engine, advancing its findings into clinical trials to change the landscape of ALS treatment.

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