Bernhardt Lab

We are a diverse team of doctors, engineers and scientists with interdisciplinary backgrounds working in sync towards the goal of translating innovative and cutting-edge technologies into the clinic for improving pediatric patient care. Our research approaches include new device development, innovative applications of existing technologies and clinical data review. Our current projects and collaborations are focused on congenital heart diseases and thoracic surgery.

The overall goal of the Sampson Lab is to help improve the health of children with nephrotic syndrome through applied genomics, with a focus on samples and data collected from patients with this condition. We use computational genomics and bioinformatics to discover new, and map known, nephrotic syndrome-associated variants. We use systems genomics to integrate this genetic data with other genome-scale molecular datasets to try to understand the mechanisms linking these genetic changes with disease. And we use epidemiology to discover the clinical consequences for patients carrying disease-associated genetic variants.

The Laboratory of Structural Cell Biology, led by Dr. Stephen C. Harrison, is situated in two physical locations within the Harvard Medical School Department of Biological Chemistry and Molecular Pharmacology and the Boston Children's Hospital Laboratory of Molecular Medicine. As a part of the Harvard Medical School Center for Molecular and Cellular Dynamics, the laboratory focuses on advancing the frontiers of structural biology through innovative research on viruses, antibodies, vaccines, and kinetochores. The lab is committed to exploring complex biological systems and has an extensive publication record that reflects its contributions to the field. With opportunities for postdoctoral research, it fosters a collaborative environment for scientists dedicated to understanding cellular mechanisms at a molecular level. Generated from the website