Samuel Chi-Hung Yiu, MD

Jefferson Doyle, M.D., Ph.D., M.H.S. specializes in pediatric ophthalmology and genetic eye diseases and is the recipient of the 2023 Andreas C. Dracopoulos & Daniel Finkelstein, M.D. Rising Professorship in Ophthalmology. His main focus is pediatric and juvenile forms of cataracts, glaucoma, anterior segment dysgenesis, and ectopia lentis. His genetics interests include Marfan syndrome and related connective tissue disorders, complex inherited forms of strabismus in both children and adults (e.g. CFEOM, Duane syndrome), and pediatric retinal dystrophies.Dr. Doyle has published extensively on a number of genetic disorders over the past decade, holds several patents for novel therapeutic approaches to treat them, and has given many national and international talks about them. Dr. Doyle's main research focus is understanding the genetic causes and molecular mechanisms driving genetic diseases, and utilizing that knowledge to develop new therapeutic strategies for them.Over the past decade, he has played a significant role in advancing our understanding of Marfan syndrome and related connective tissue disorders. His work and that of collaborators has led to the discovery of the genetic causes of Shprintzen-Goldberg syndrome and Loeys-Dietz like syndrome. His work has also led to a much better understanding of the molecular mechanisms driving Marfan syndrome, and he holds two patents for novel therapeutic strategies to treat it.Part of his current work focuses on the identification of genes that protect people from developing a number of genetic disorders, and leveraging that knowledge to develop new therapies for those diseases. He also has an interest in pediatric myopia, and has ongoing pre-clinical studies seeking to understand the mechanisms that may drive it and the development of novel therapeutic strategies to treat it.

Dr. Ashish Doshi is a pediatric cardiologist specializing in advanced cardiac imaging at Johns Hopkins Children’s Center in Baltimore, Maryland.Dr. Doshi completed a combined M.D./Ph.D. program at Duke University School of Medicine. His doctoral research was in the field of biomedical engineering, specifically computational modeling of cardiac electrophysiology. He completed his pediatrics residency at St. Louis Children’s Hospital, followed by a fellowship in pediatric cardiology at Children’s National Hospital in Washington, DC. During his cardiology fellowship, Dr. Doshi conducted research at The Johns Hopkins University School of Engineering. After finishing fellowship, he continued this work through a research fellowship funded by the American Heart Association, investigating MRI-based computational models for arrhythmia risk prediction in tetralogy of Fallot and pediatric myocarditis. He subsequently completed training in advanced cardiac imaging at Johns Hopkins Children’s Center.Dr. Doshi’s research interests involve the use of computational methods, particularly image-based biomedical modeling and computer simulation, for risk stratification and clinical decision support in children with congenital and acquired heart disease, with particular interests in hypertrophic cardiomyopathy, repaired tetralogy of Fallot, and single-ventricle disease. He has also conducted work in fetal electrocardiography and the use of cardiac MRI native T1 mapping for detection of heart transplant rejection.