Brad R.
11/12/2025
TLDR: A classic New Orleans spot serving some of the best po-boys in the city. Worth the wait every single time. Domilise's Po-Boys & Bar is a true New Orleans staple that's been serving...
Domilise Po-Boys & Bar
$
Closed
(745)
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5240 Annunciation St
New Orleans, LA 70115
Domilise's Po-Boys and Bar, established in 1918, is a cherished fixture in the Uptown neighborhood of New Orleans. The family-owned establishment is renowned for its delectable po-boys, serving the community with a dedication to tradition and exceptional hospitality spanning generations.
The legacy began with Peter and Sophie Domilise, later nurtured by Dorothy "Miss Dot" Domilise and her family, who continue to welcome both locals and tourists alike as part of their family. Through the highs and lows of New Orleans history, Domilise's has remained a beloved haven where memorable meals and enduring kinship thrive.
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Reviews
4.0745 reviews
Stephen L.
10/7/2025
(10/07/2025) No frills Po' boy shop. I got the half and half seafood sandwich (half shrimp and half oyster). The oysters were fine, but not particularly flavorful; the shrimp were crispy on the...
Shelly R.
7/14/2025
I'm always on the search for the best poboy when I'm in New Orleans. I saw a clip or program short about Domilise. I had to get there. I didn't have a rental car this trip so I used public...
Alicia S.
11/27/2025
So good; so fresh!!!! Great bread and cool service. Got the seafood half and half. Yum.
Ted R.
6/15/2025
Large shrimp po' boy dressed was huge and one of the best I've had. Worth $16. Delicious fries too. They serve Abita Turbo Dog, which goes well with the eats! Merch and memorabilia celebrating...
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