Johnsonlab

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800 Rose St Ste 567
Lexington, KY 40536
+1 (859) 323-2746
http://www.ljohnsonlab.com

Johnson Lab, located in Lexington, KY, specializes in understanding the role of the Alzheimer's disease risk factor Apolipoprotein E (APOE) in cerebral metabolism, with a strong emphasis on glial cells and their impact on neurodegeneration. Utilizing a range of transcriptomic and metabolomic techniques, the lab aims to identify early-life metabolic changes associated with APOE and to discover therapeutic targets that enhance cognitive resilience and extend brain health spans.

The lab has recently launched an interactive APOE Immunometabolism Database and continues to expand its research team alongside ongoing projects that explore various aspects of metabolism in relation to APOE and Alzheimer's disease. Highlighting innovative convergences in research, such as the novel APOE switch mouse model, Johnson Lab seeks to examine the therapeutic potential of modulating APOE alleles and understanding their implications in neuroprotection and metabolic dysfunction.

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