UCI School of Pharmacy and Pharmaceutical Sciences

The Pathak Lab, located in Irvine, CA, is dedicated to exploring the complex interactions between mechanical forces and neural stem cell fate at various biological levels. Their research emphasizes the role of the stretch-activated ion channel Piezo1 in mediating the mechanosensitive specification of neural stem cells, influencing their differentiation into neurons or astrocytes. Employing a multi-disciplinary approach, the lab integrates techniques from ion channel biophysics, cell biology, optical imaging, stem cell biology, and bioengineering. Current investigations focus on elucidating the mechanisms by which Piezo1 detects mechanical signals from the extracellular matrix, how it affects gene expression, and its potential implications in neural development and disease states. Generated from the website

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