Entero Therapeutics

Targacept is a biopharmaceutical company engaged in the design, discovery and development of a new class of drugs to treat diseases and disorders of the central nervous system. It is a leader in the field of neuronal nicotinic acetylcholine receptor chemistry and biology. NNRs are found on nerve cells throughout the nervous system and serve as key regulators of nervous system activity. Targacept s product candidates are designed to selectively target specific NNR subtypes and promote therapeutic effects and limit adverse side effects. Targacept has product candidates in clinical development for cognitive impairment, including Alzheimer s disease and age-associated memory impairment, pain and depression. From 1997 to 2000, Targacept was a subsidiary of R. J. Reynolds Tobacco Company. During this time, the company s investigations into the biological effects of nicotine suggested a role for NNRs in the treatment of human disease and led to the creation of Targacept.

Allergan is a global specialty pharmaceutical company that develops and commercializes innovative products for the eye care, neuromodulator, skin care and other specialty markets. The company offers Alphagan, Alphagan P, Lumigan, and Restasis products for the treatment of glaucoma, and Acular, Elestat, and Alocril for the temporary relief of itch and for postoperative inflammation. It also offers Acular PF for the reduction of ocular pain and photophobia. It provides Acular LS for the reduction of ocular pain, burning and stinging, Ocuflox, an anti-infective ophthalmic solutions, and Zymar for bacterial conjunctivitis. Allergan s neuromodulator products include Botox that is used for neuromuscular disorders. The firm s skin care products include Tazorac gel for plaque psoriasis and acne, Avage for facial fine wrinkling, Azelex for mild to moderate inflammatory acne vulgaris, M.D. Forte, a glycolic acid-based skin care products, and Finacea for the treatment of rosacea. David E. I. Pyott has been the chief executive officer of Allergan for more than eight years. He has been with the drugs and bio-tech company for over eight years. Pyott earned a BS degree from the University of Edinburgh, and a MS degree from London University College. Allergan has global marketing and sales capabilities in more than 100 countries, and is located in Irvine, Calif.