The Guadalupe on Main

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(197)

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1526 E Main St
Mesa, AZ 85203

The Guadalupe on Main in Mesa, AZ, offers a craft kitchen and cocktail experience on Main Street. Specializing in flavors from Jalisco, the restaurant provides a gluten-free friendly Mexican menu, inviting guests to savor authentic dishes.

With a focus on quality ingredients and innovative recipes, The Guadalupe on Main aims to create a unique dining experience for patrons seeking a taste of traditional Mexican cuisine with a modern twist.

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Reviews

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4.5197 reviews
Photo of John S.
John S.
8/7/2025

Owning and running a restaurant is a tough and sometimes thankless business. Been there, done that. This place seems to be an "it" place for now, but I'm not exactly sure why. This was the loudest...

Photo of Danielle N.
Danielle N.
7/30/2025

Probably the highest quality mexican food I've had in a long time and all gluten free! This is my second time coming here. Unfortunately, the first time I got very sick because I have a severe...

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Shayley G.
7/24/2025

Great food! Fun local vibe. Mushroom app was to die for 10/10 Ceviche was meh 6/10 Mahi Tacos fantastic (for az seafood) 8/10 Mole enchiladas was good if you like mole 7/10 For sure will be...

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Alisha O.
7/24/2025

I'm not sure if we ordered the wrong things this time but not as great an experience. We got the queso which should really be described differently. It's not very cheesy, more like a corn and...

Photo of Brad N.
Brad N.
6/15/2025

This place was a pleasant surprise. My wife and I are from Texas, and we were here with a group of friends who had flown in from all over, Chicago, North Carolina, and Dallas, and some locals....

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