The centerpiece of Milan, the Duomo is one of Europe’s greatest architectural and cultural landmarks. As Italy’s largest church and one of the largest in the world, it took over 600 years to build. Today, the Duomo has a capacity of 40,000 people and is home to the world’s second-largest organ. Admire the wide selection of religious art on display inside, or marvel at the 3000 statues that line its Gothic exterior. Be sure to join one of the available Duomo tours, which include art tours and even rooftop tours, where you might be able to see as far as the Italian Alps. – Tripadvisor